A scientometric evaluation reveals key analysis developments

A current examine printed in Frontiers in Immunology examines the connection between intestine microbiota (GM) and a number of sclerosis (MS).

Examine: Relationship between intestine microbiota and a number of sclerosis: a scientometric visible evaluation from 2010 to 2023. Picture Credit score: Kateryna Kon / Shutterstock.com

The gut-brain-axis and MS

MS is a power inflammatory illness of the central nervous system (CNS) and is among the many commonest causes of neurologic incapacity in individuals between 18 and 40 years of age. The etiology of MS is multifactorial and heterogeneous, as it’s influenced by each environmental and genetic elements.

The human GM encodes over three million genes and produces hundreds of metabolites that facilitate bidirectional communication between the CNS and gastrointestinal system. A number of research have correlated GM imbalance to MS pathogenesis.

Bibliometric analyses are broadly used to look at improvement developments, analysis hotspots, self-discipline information construction, and tutorial affect in particular analysis areas utilizing statistical and mathematic strategies. Regardless of hundreds of research printed on the connection between GM and MS, there stays an absence of bibliometric analyses.

In regards to the examine

Within the current examine, researchers carried out a scientometric evaluation of analysis on the connection between GM and MS. Related research printed between 2010 and 2023 have been searched within the Internet of Science Core Assortment.

Information obtained from the search process have been visually analyzed utilizing a number of instruments. Cooperative networks involving authors, key phrases, journals, nations, and establishments have been generated.

Outstanding surges in publications and cited journals have been recognized, and development matters have been analyzed.

Examine findings

General, 1,019 publications have been recognized, with a steady progress fee within the annual publication quantity reported between 2010 and 2013. In 2018, a major enhance in publications was noticed, with the annual quantity exceeding 100 articles for the primary time.

Rising curiosity within the relationship between GM and MS was noticed as publications peaked between 2021 and 2023. The reviewed research have been carried out in 70 nations and areas, with Canada and the USA collaborating essentially the most, adopted by the U.S. and Germany.

The U.S., Italy, Germany, China, and Canada accounted for 72% of all publications. General, 1,581 distinct establishments contributed to those publications, with the College of California and Harvard Medical College as the highest two contributing universities.

A complete of 5,185 authors contributed to the reviewed publications, two of whom had the best publications and have been much less collaborative with others. The writer with essentially the most publications additionally had the best variety of citations.

The reviewed articles have been printed in a complete of 359 journals. The highest 5 journals included A number of Sclerosis Journal, Frontiers in Immunology, Worldwide Journal of Molecular Sciences, Vitamins, and A number of Sclerosis and Associated Issues. The highest three publications have been cited over 500 occasions, with 796 citations recognized for a single article.

Key phrase co-occurrence networks have been created, and every key phrase had a minimal frequency of 5. The key phrase community was stratified into 5 clusters comprising 52, 30, 30, 24, and 30 key phrases, respectively.

The primary cluster concerned key phrases associated to the position of eating regimen in autoimmune illnesses and the impression of probiotics and microbiome on autoimmunity. The second cluster centered on the connection between GM and systemic immune-mediated illnesses.

The third cluster included key phrases on the associations and mechanisms between GM and neurologic illnesses. The fourth cluster included microglia, ketogenic eating regimen, neurodegeneration, dysbiosis, neuroinflammation, and immunity. The ultimate cluster concerned key phrases on psychological well being, particularly despair.

Experimental autoimmune encephalomyelitis (EAE) was essentially the most ceaselessly used mouse mannequin for MS. GM was additionally related to neurodegenerative illnesses, similar to Alzheimer’s illness and Parkinson’s illness.

Probably the most distinguished key phrases earlier than 2018 have been autoimmune illness, immunity, estrogen, inflammatory bowel illness, and T helper 17 (Th17) cells, which displays that analysis was targeted on the position of GM within the immune mechanisms of MS. Between 2019 and 2020, the commonest key phrases have been EAE, MS, microbiome, and irritation, thus suggesting analysis concentrate on the position of GM in scientific research and animal fashions.

After 2021, high-frequency key phrases included the gut-brain axis, probiotics, dysbiosis, getting old, and neurodegenerative illness. This commentary signifies a analysis transition, with an emphasis on understanding the impression of GM in getting old and neurodegenerative illnesses.

Conclusions

The emergence of instruments similar to metagenomic shotgun sequencing and 16s ribosomal ribonucleic acid (rRNA) gene pyrosequencing has considerably contributed to the rising variety of analysis research investigating the connection between GM and MS. Future research are wanted to look at the position of intestine dysbiosis in MS pathogenesis and examine the underlying interplay mechanisms between GM and MS.